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1: J Biomed Sci. 1998;5(1):24-7.Links

Tat, Tat-associated kinase, and transcription.

Jeang KT.

Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, MD 20892-0460, USA. kj7e@nih.gov

The HIV-1 Tat protein is an RNA-binding transcriptional transactivator. Recent findings suggest that Tat associates with a cellular kinase that phosphorylates the carboxyl-terminal domain of the largest subunit of RNA polymerase II. Here we review, in brief, the role of Tat-associated kinase in Tat-activated transcription. We discuss evidence that suggests involvement of TFIIH and/or P-TEFb.

PMID: 9570510 [PubMed - indexed for MEDLINE]