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Curr Opin Neurobiol. 1998 Feb;8(1):106-16.

An emerging link between cytoskeletal dynamics and cell adhesion molecules in growth cone guidance.

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  • 1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520-8103, USA.


It has become increasingly evident that growth cone guidance depends on the concerted actions of cytoskeletal proteins, molecular motors and cell adhesion molecules. Recent studies suggest that modulation of coupling between extracellular substrates and intracellular cytoskeletal networks via cell surface receptors is an important mechanism for regulating directed neuronal growth.

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