Curr Opin Cell Biol. 1998 Apr;10(2):188-94.

Mads and Smads in TGF beta signalling.

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Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada.

Abstract

The discovery of the Mothers against dpp (Mad) gene in Drosophila has opened a window on an entirely unique signalling pathway that functions to mediate responses to the tumour growth factor beta (TGF beta) superfamily. This pathway, which is comprised of a family of proteins related to Mad, acts to convey signals directly from TGF beta receptors to the nucleus and is implicated in the pathogenesis of human diseases.

PMID:: 9561843; [PubMed - indexed for MEDLINE]

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