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Nature. 1998 Apr 9;392(6676):565-8.

Chemokines and leukocyte traffic.

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  • 1Theodor Kocher Institute, University of Bern, Switzerland.


Over the past ten years, numerous chemokines have been identified as attractants of different types of blood leukocytes to sites of infection and inflammation. They are produced locally in the tissues and act on leukocytes through selective receptors. Chemokines are now known to also function as regulatory molecules in leukocyte maturation, traffic and homing of lymphocytes, and the development of lymphoid tissues.

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