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Minerva Pediatr. 1997 Oct;49(10):499-504.

[A case report of reversible biliary pseudolithiasis caused by ceftriaxone in childhood: does the problem deserve greater attention?].

[Article in Italian]

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  • 1Unità Operativa Pediatrico Neonatologica, Presidio Ospedaliero di Vasto, Regione Abruzzo, Azienda USL Lanciano, Vasto, Chieti.


The authors report the case of a nine-year-old girl admitted to hospital with signs of meningeal irritation during the course of hyperpyretic phlogosis of the upper airways who presented, after 6 days' treatment with CFTX, at a dose of 50 mg/kg/day (1.5 g/day), therefore at the maximum recommended dose for the antibiotic in question, symptomatic cholecystic "pseudolithiasis" which resolved two weeks after the suspension of the drug. This case appears to concord with recent reports of "pseudolithiasis" in childhood that appeared with doses not regarded as being at risk, and it draws attention to the etiopathogenetic importance of other factors, including familial recurrence. The authors recommend a reasonable use of CFTX and the need to be "vigilant" both in relation to the onset and evolution of the clinical condition described above.

[PubMed - indexed for MEDLINE]
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