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Prog Cell Cycle Res. 1996;2:73-82.

The functions of Myc in cell cycle progression and apoptosis.

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  • 1Zentrum für Molekulare Biologie Heidelberg (ZMBH).


c-myc has emerged as one of the central regulators of mammalian cell proliferation. The gene encodes a transcription factor of the HLH/leucine zipper family of proteins that activates transcription as part of a heteromeric complex with a protein termed Max. In mammalian fibroblasts, Myc acts as an upstream regulator of cyclin-dependent kinases and functionally antagonises the action of at least one cdk inhibitor, p27. Myc also induces cells to undergo apoptosis, and the relationship between Myc-induced cell cycle entry and apoptosis is discussed.

[PubMed - indexed for MEDLINE]
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