Send to:

Choose Destination
See comment in PubMed Commons below
Prog Cell Cycle Res. 1995;1:163-72.

The role of the Ran GTPase pathway in cell cycle control and interphase nuclear functions.

Author information

  • 1Laboratory of Molecular Embryology, NICHD, National Institutes of Health, Bethesda, MD 20892-5430, USA.


Ran is a small, highly abundant, nuclear GTPase. Mutants in Ran and in proteins that interact with it disrupt the normal checkpoint control of mitosis with respect to the completion of DNA synthesis. Ran and other components of this pathway are also required for numerous nuclear functions such as RNA export, protein import, RNA processing and DNA replication. It will be important to understand how these facets of Ran's activities are linked and how they promote correct control of the cell cycle. This review examines recent progress in discovering other components of the Ran GTPase pathway and considers how this pathway may be required for the control of the cell cycle.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk