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Stat Med. 1998 Mar 15-Apr 15;17(5-7):767-79.

A comparative analysis of quality of life data from a Southwest Oncology Group randomized trial of advanced colorectal cancer.

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  • 1Columbia University School of Public Health, New York, NY 10032, USA.


Longitudinal quality of life measurements from an advanced-stage cancer clinical trial are analysed using a variety of methods, and the results compared. The methods used require different assumptions about the mechanism that produces the missing data. They include analyses that require the data to be missing completely at random; fixed-effects models and weighted generalized estimating equations, which require missing at random data; and a fully parametric approach where the outcomes and the missingness mechanism are jointly modelled, allowing non-ignorable missing data. The data show evidence of non-random missingness, but a formal test of non-ignorable missing data is not significant.

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