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Nihon Rinsho. 1998 Mar;56(3):701-4.

[Gene delivery using adeno-associated (AAV) vectors].

[Article in Japanese]

Author information

  • 1Department of Clinical & Laboratory Medicine, Tohoku University, School of Medicine.

Abstract

Gene transfer vectors based on the replication-defective adeno-associated virus (AAV) are emerging as promising vehicles for gene therapeutic approaches for the neurologic disease, cystic fibrosis and cancers. AAV vectors have been used to efficiently transduce genes into cells in vitro and in vivo. However, transduced recombinant AAV vectors are integrated into human chromosomes. Thus we have discussed that the review about the AAV vectors and transduction, and reported the results used AAV vectors for expression of ribozyme.

PMID:
9549360
[PubMed - indexed for MEDLINE]
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