Changes in auditory P300 in patients with major depression and silent cerebral infarction

J Affect Disord. 1997 Dec;46(3):263-71. doi: 10.1016/s0165-0327(97)00100-6.

Abstract

We examined event-related potentials in patients with senile depression and silent cerebral infarction (SCI) to clarify the features of the P300 component. P300 event-related potentials were recorded in drug-free depressed patients (N = 16) and normal controls (N = 17). All patients underwent magnetic resonance imaging and were classified as SCI-positive (N = 7) or SCI-negative (N = 9). In depressed patients, the P300 was reexamined after antidepressant treatment. Prior to treatment, P300 amplitudes in depressed patients were significantly smaller than those in normal controls (P < 0.01). P300 amplitudes increased significantly in SCI-negative patients following recovery (P < 0.05), but did not change in SCI-positive patients. SCI may interrupt the treatment-related P300 amplitude increase in depressed patients.

MeSH terms

  • Age Factors
  • Aged
  • Antidepressive Agents / therapeutic use
  • Brain / pathology
  • Cerebral Infarction / diagnosis*
  • Cerebral Infarction / epidemiology
  • Cerebral Infarction / pathology
  • Comorbidity
  • Depressive Disorder / diagnosis*
  • Depressive Disorder / drug therapy
  • Depressive Disorder / epidemiology
  • Event-Related Potentials, P300*
  • Evoked Potentials, Auditory*
  • Female
  • Humans
  • Japan / epidemiology
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Prospective Studies

Substances

  • Antidepressive Agents