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Science. 1998 Apr 17;280(5362):427-31.

Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection.

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  • 1New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Post Office Box 9102, Southborough, MA 01772, USA.

Abstract

Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4(+) T cells, a cell type that is abundant in the intestine. SIV infection of rhesus monkeys resulted in profound and selective depletion of CD4+ T cells in the intestine within days of infection, before any such changes in peripheral lymphoid tissues. The loss of CD4+ T cells in the intestine occurred coincident with productive infection of large numbers of mononuclear cells at this site. The intestine appears to be a major target for SIV replication and the major site of CD4+ T cell loss in early SIV infection.

PMID:
9545219
[PubMed - indexed for MEDLINE]
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