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Immunoglobulins and transient paraproteins in sera of patients with the Wiskott-Aldrich syndrome: a follow-up study.
Immunoglobulin levels of individual classes and IgG subclasses and the occurrence of homogeneous immunoglobulins--paraproteins--were studied longitudinally in the sera of three patients with the Wiskott-Aldrich syndrome; Common findings in all three patients were great variations in the immunoglobulin levels, restricted heterogeneity of the immunoglobulins, the frequent appearance of transient homogeneous immunoglobulins and the presence of serum antibodies against bovine milk proteins. A partial and selective deficiency involving mainly the T immune system is postulated as an explanation for these findings.
PMID: 954233 [PubMed - indexed for MEDLINE]
PMCID: PMC1541349
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Cited by 8 PubMed Central articles
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Systemic vasculitis and aneurysm formation in the Wiskott-Aldrich syndrome.
McCluggage WG, Armstrong DJ, Maxwell RJ, Ellis PK, McCluskey DR.
J Clin Pathol. 1999 May; 52(5):390-2.
[J Clin Pathol. 1999]
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B cell hyperactivity and abnormalities in T cell markers and immunoregulatory function in a patient with nucleoside phosphorylase deficiency.
Zabay JM, De La Concha EG, Ludeña C, Lozano C, Pascual-Salcedo D, Bootello A, Gonzalezporqué P.
Clin Exp Immunol. 1982 Dec; 50(3):610-6.
[Clin Exp Immunol. 1982]
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Monoclonal immunoglobulin-secreting lymphoma in a patient with severe combined immunodeficiency disease.
Shirley LR, Buckley RH, Borowitz MJ, Welt SI, Kostyu DD.
Clin Exp Immunol. 1982 Jun; 48(3):666-74.
[Clin Exp Immunol. 1982]
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