J Biochem. 1998 Mar;123(3):369-75.

Structure and function of bacterial cytochrome c oxidase.

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Uppsala University, Department of Biochemistry, Biomedical Center, BOX 756 S-75123 Uppsala, Sweden. iwata@xray.bmc.uu.se

Abstract

The crystal structure of cytochrome c oxidase from the soil bacterium Paracoccus denitrificans has been reported. This structure has provided a basis for understanding the mechanism of the redox-coupled transmembrane proton pump which is the key component of the respiratory chain in most aerobic organism. Over the past ten years, there have been many site-directed mutagenesis studies performed on bacterial oxidases. Structural features of Paracoccus oxidase have been summarized in the light of these mutagenesis studies and other structural works.

PMID:: 9538216; [PubMed - indexed for MEDLINE]

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