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    Clin Exp Rheumatol. 1998 Mar-Apr;16(2):175-80.

    HIV infection and SLE: their pathogenic relationship.

    Sekigawa I, Kaneko H, Hishikawa T, Hashimoto H, Hirose S, Kaneko Y, Maruyama N.

    Department of Medicine, Juntendo University, Izu-Nagaoka Hospital, Shizuoka, Japan.

    Retroviruses have repeatedly been suggested as a possible trigger mechanism for systemic lupus erythematosus (SLE). We review the role of human immunodeficiency virus (HIV)-1 envelope glycoprotein (gp120) in the induction of immune dysregulation including autoimmunity in HIV-1 infection, and discuss the possible relationship between HIV and SLE in the retroviral etiology.

    PMID: 9536396 [PubMed - indexed for MEDLINE]

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