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    Science. 1998 Apr 10;280(5361):295-8.

    The involvement of cell-to-cell signals in the development of a bacterial biofilm.

    Davies DG, Parsek MR, Pearson JP, Iglewski BH, Costerton JW, Greenberg EP.

    Source

    Center for Biofilm Engineering, Montana State University, Bozeman, MT 59717-3980, USA.

    Abstract

    Bacteria in nature often exist as sessile communities called biofilms. These communities develop structures that are morphologically and physiologically differentiated from free-living bacteria. A cell-to-cell signal is involved in the development of Pseudomonas aeruginosa biofilms. A specific signaling mutant, a lasI mutant, forms flat, undifferentiated biofilms that unlike wild-type biofilms are sensitive to the biocide sodium dodecyl sulfate. Mutant biofilms appeared normal when grown in the presence of a synthetic signal molecule. The involvement of an intercellular signal molecule in the development of P. aeruginosa biofilms suggests possible targets to control biofilm growth on catheters, in cystic fibrosis, and in other environments where P. aeruginosa biofilms are a persistent problem.

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    PMID:
    9535661
    [PubMed - indexed for MEDLINE]

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