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Pediatr Neurol. 1998 Feb;18(2):165-8.

Successful use of intravenous immunoglobulins in Landau-Kleffner syndrome.

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  • 1University Hospital Gasthuisberg; Department of Pediatrics; Leuven, Belgium.


A detailed history of a boy with Landau-Kleffner syndrome is presented, demonstrating a close relationship between language functioning and paroxysmal electroencephalogram activity. During a 3-year 6-month follow-up period, three abrupt deteriorations of all language functions occurred: the child became totally noninteractive with his environment within 1 week's time. Two of these deteriorations were reversed with steroid treatment, with an identical recovery phase. Intravenous immunoglobulins had a very dramatic and comparable effect in the third relapse; both language functions and electroencephalogram abnormalities were influenced significantly by the intravenous immunoglobulin treatment.

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