J Protein Chem. 1998 Feb;17(2):143-8.

Isolation and characterization of full and truncated forms of human breast carcinoma protein BA46 from human milk fat globule membranes.

Giuffrida MG, Cavaletto M, Giunta C, Conti A, Godovac-Zimmermann J.

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Institut für Molekulare Biotechnologie, Jena, Germany.

Abstract

We have isolated and characterized two proteins of 50 and 30 kDa from human milk fat globule membranes of healthy donors. N-terminal and internal sequencing revealed that the 50-kDa protein is the full-length human breast carcinoma protein BA46 that is highly expressed in human breast tumors. The 30-kDa protein is a truncated form of protein BA46 which consists of the C-terminal factor V/VIII-like domain of BA46 and which appears to anchor BA46 to the milk fat globule membrane. Defective release of the epidermal growth factor domain containing a surface RGD motif may be related to involvement of BA46 in breast cancer.

PMID:: 9535276; [PubMed - indexed for MEDLINE]

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