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Br J Obstet Gynaecol. 1998 Mar;105(3):300-3.

A randomised controlled trial of intravenous magnesium sulphate versus placebo in the management of women with severe pre-eclampsia.

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  • 1Department of Obstetrics and Gynaecology, University of Cape Town, Groote Schuur Hospital, South Africa.

Abstract

OBJECTIVE:

To determine whether the administration of prophylactic intravenous magnesium sulphate reduces the occurrence of eclampsia in women with severe pre-eclampsia.

DESIGN:

Randomised controlled trial.

SETTING:

A tertiary referral obstetric unit.

POPULATION:

Eight hundred and twenty-two women with severe pre-eclampsia requiring termination of pregnancy by induction of labour or caesarean section.

METHODS:

The women were randomised to receive either placebo (saline) or magnesium sulphate intravenously. The investigators were blinded to the contents of the pre-mixed solutions.

MAIN OUTCOME MEASURE:

The occurrence of eclampsia in the two groups.

RESULTS:

The data of 699 women were evaluated. Fourteen were withdrawn after randomisation. The overall incidence of eclampsia was 1.8%. Of 345 women who received magnesium sulphate, one developed eclampsia (0.3%); in the placebo group, 11/340 women (3.2%) developed eclampsia (relative risk 0.09; 95% confidence interval 0.01-0.69; P = 0.003).

CONCLUSION:

The use of intravenous magnesium sulphate in the management of women with severe pre-eclampsia significantly reduced the development of eclampsia.

Comment in

PMID:
9532990
[PubMed - indexed for MEDLINE]
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