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1: J Pept Res. 1998 Mar;51(3):173-9.Links

The contryphans, a D-tryptophan-containing family of Conus peptides: interconversion between conformers.

Jacobsen R, Jimenez EC, Grilley M, Watkins M, Hillyard D, Cruz LJ, Olivera BM.

Department of Biology, University of Utah, Salt Lake City 84112, USA.

We previously characterized contryphan-R, a D-tryptophan-containing octapeptide from the venom of Conus radiatus. In this study, we present evidence that the contryphan family of peptides is widely distributed in venoms of the fish-hunting cone snails. We purified, synthesized and characterized contryphan-Sm from Conus stercusmuscarum venom, and obtained molecular evidence for the existence of a third peptide, contryphan-P from Conus purpurascens venom ducts. The sequences of these three contryphans showed identity in seven of eight amino acids and a conserved pattern of post-translational modification. We also demonstrate that contryphan-Sm equilibrates between two distinct conformational states.

PMID: 9531419 [PubMed - indexed for MEDLINE]

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