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J Trauma. 1998 Mar;44(3):446-53.

Effects of intra-abdominal hypertension on hepatic energy metabolism in a rabbit model.

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  • 1Trauma and Critical Care Center, Teikyo University School of Medicine, Itabashi, Tokyo, Japan.

Abstract

BACKGROUND:

Intra-abdominal hypertension is known to decrease hepatic blood flow, but its effect on hepatic energy level has not described.

METHODS:

Fifty-three rabbits were mechanically ventilated and divided into five groups. Intra-abdominal hypertension was induced by saline infusion and maintained for 30 minutes. Hepatic sinusoidal functional blood flow was evaluated by means of indocyanine green disappearance rate (ICG-K), hepatic mitochondrial redox status was evaluated by arterial ketone body ratio, and tissue energy level was evaluated by energy charge (EC).

RESULTS:

At an intra-abdominal pressure of 20 mm Hg, ICG-K was significantly decreased, with no decrease in EC. At 30 mm Hg, hypoxemia developed and the ICG-K decreased further, with significant decreases observed in arterial ketone body ratio and EC. The latter were not increased by administration of oxygen.

CONCLUSION:

At an intra-abdominal pressure of 20 mm Hg, a slight decrease in sinusoidal flow did not affect hepatic energy level. At 30 mm Hg, a reduced hepatic mitochondrial redox status and a decreased energy level were attributed to a decrease in sinusoidal flow in this animal model.

PMID:
9529170
[PubMed - indexed for MEDLINE]
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