Antimicrobial resistance in Shigella flexneri and Shigella sonnei in Hong Kong, 1986 to 1995

Y W Chu; E T Houang; D J Lyon; J M Ling; T K Ng; A F Cheng

doi:10.1128/AAC.42.2.440

Antimicrobial resistance in Shigella flexneri and Shigella sonnei in Hong Kong, 1986 to 1995

Antimicrob Agents Chemother. 1998 Feb;42(2):440-3. doi: 10.1128/AAC.42.2.440.

Authors

Y W Chu¹, E T Houang, D J Lyon, J M Ling, T K Ng, A F Cheng

Affiliation

¹ Department of Microbiology, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, New Territories.

Abstract

Three hundred and thirty-three Shigella isolates obtained in 1986 to 1995 were tested for their susceptibilities to 19 antimicrobial agents. Nalidixic acid resistance had emerged in 59.6% of Shigella flexneri isolates during 1994 to 1995, with all tested resistant isolates having the mutation in gyrA encoding the Ser-83 alteration. Multiresistance (resistance to four or more agents) was more common in S. flexneri than in Shigella sonnei.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / pharmacology*
DNA Gyrase
DNA Topoisomerases, Type II / genetics
Drug Resistance, Multiple / genetics
Hong Kong
Humans
Microbial Sensitivity Tests
Nalidixic Acid / pharmacology*
Shigella flexneri / drug effects*
Shigella flexneri / genetics
Shigella sonnei / drug effects*
Shigella sonnei / genetics

Substances

Anti-Infective Agents
Nalidixic Acid
DNA Gyrase
DNA Topoisomerases, Type II