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J Virol. 1998 Apr;72(4):3479-83.

Induction of mucosal B-cell memory by intramuscular inoculation of mice with rotavirus.

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  • 1Division of Immunologic and Infectious Diseases, The Children's Hospital of Philadelphia, and The University of Pennsylvania School of Medicine, 19104, USA. coffin@email.chop.edu


We investigated the capacity of intramuscular (i.m.) immunization with heterologous-host rotavirus (simian strain RRV) to induce mucosal virus-specific memory B cells in mice. We found that prior i.m. immunization enhanced the magnitude of mucosal virus-specific immunoglobulin A (IgA) production but did not alter the site and timing of induction of virus-specific IgA responses after challenge.

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