Psychiatry Res. 1979 Oct;1(2):131-9.

Aggression in humans correlates with cerebrospinal fluid amine metabolites.

Brown GL, Goodwin FK, Ballenger JC, Goyer PF, Major LF.

Abstract

Cerebrospinal fluid of the major central metabolites of serotonin (5HT), norepinephrine (NE), and dopamine (DA)--5-hydroxyindoleacetic acid (5HIAA), 3-methoxy-4-hydroxy=phenylglycol (MHPG), and homovanillic acid (HVA), respectively--were studied in a group of 26 age-similar military men with no history of major psychiatric illness, but with various personality disorders and difficulties adjusting to military life. Independently scored history of aggressive behavior showed a significant negative correlation with 5HIAA (r = -0.78) and a significant positive correlation with MHPG (r = 0.64).

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Aggression in humans correlates with cerebrospinal fluid amine metabolites.

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Cited by 39 PubMed Central articles

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