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Curr Opin Struct Biol. 1998 Feb;8(1):14-8.

Helicases: a unifying structural theme?

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  • 1Sir William Dunn School of Pathology, University of Oxford, UK.


The recent structure determinations of PcrA DNA helicase, NS3 RNA helicase, and Rep DNA helicase have revealed similarities between their folds. When these data are examined with sequence and biochemical analyses, as well as microscopy studies of hexameric helicases, a picture of a unifying structure and mechanism for all helicases is beginning to emerge.

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