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J Bacteriol. 1998 Mar;180(6):1570-2.

Melanin biosynthesis in Cryptococcus neoformans.

Author information

  • 1Division of Infectious Diseases, University of Illinois at Chicago College of Medicine, 60612, USA. prw@uic.edu

Abstract

Pigment production by Cryptococcus neoformans is virulence associated. Dopamine- and 3,4-dihydroxyphenylalanine-melanin products were identified after acidic permanganate oxidation, alkaline hydrogen peroxide oxidation, or hydrolysis with hydriodic acid. These data provide direct chemical evidence for the formation of eumelanin polymers by catecholamine oxidation by laccase alone followed by oxidative coupling of dihydroxyindole.

PMID:
9515929
[PubMed - indexed for MEDLINE]
PMCID:
PMC107060
Free PMC Article

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