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Am J Surg. 1998 Feb;175(2):87-90.

Duration of antimicrobial prophylaxis in vascular surgery.

Author information

  • 1Department of General Surgery, Royal Perth Hospital, Australia.

Abstract

BACKGROUND:

This randomized clinical trial compares the incidence of wound infection after vascular surgery in patients who received prophylaxis using the same antibiotic as either a single-dose or a multiple-dose regimen (until the lines/drain tubes were removed, but not for more than 5 days).

METHODS:

Each of the 302 patients who entered the study received ticarcillin 3.0 g/clavulanate 0.1 g (Timentin) intravenously immediately after the induction of anesthesia. Patients randomized to the multiple-dose group received an average of 14.3 doses (range 9 to 20).

RESULTS:

The incidence of wound infections was 18% (28 of 153) for patients in the single-dose group and 10% (15 of 149) for patients in the multiple-dose group (P = 0.04; relative risk estimate = 2.00, 95% confidence interval = -1.02 to 3.92).

CONCLUSIONS:

A multiple-dose antibiotic regimen, rather than single-dose therapy, provides optimal prophylaxis against wound infection for patients undergoing vascular surgery.

PMID:
9515521
[PubMed - indexed for MEDLINE]
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