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Fold Des. 1998;3(1):R9-23.

Protein aggregation: folding aggregates, inclusion bodies and amyloid.

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  • 1Department of Chemistry and Biochemistry, University of California, Santa Cruz 95064, USA. enzyme@cats.ucsc.edu

Abstract

Aggregation results in the formation of inclusion bodies, amyloid fibrils and folding aggregates. Substantial data support the hypothesis that partially folded intermediates are key precursors to aggregates, that aggregation involves specific intermolecular interactions and that most aggregates involve beta sheets.

PMID:
9502314
[PubMed - indexed for MEDLINE]
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