Antigen processing: HLA-DO--a hitchhiking inhibitor of HLA-DM

Curr Biol. 1998 Feb 12;8(4):R128-31. doi: 10.1016/s0960-9822(98)70988-1.

Abstract

Recent studies have revealed that the conserved major histocompatibility complex class II molecule, HLA-DO, inhibits the class II antigen-processing pathway. HLA-DO, expressed in only a subset of antigen-presenting cells, binds HLA-DM and blocks HLA-DM-catalyzed peptide loading of class II molecules.

Publication types

  • Review

MeSH terms

  • Antigen Presentation / immunology*
  • B-Lymphocytes / immunology
  • Catalysis
  • HLA-D Antigens / immunology*
  • Histocompatibility Antigens Class II*
  • Humans
  • T-Lymphocytes / immunology

Substances

  • H-2O antigen
  • H2-M antigens
  • HLA-D Antigens
  • HLA-DM antigens
  • HLA-DO antigens
  • Histocompatibility Antigens Class II