Abstract
Recent studies have revealed that the conserved major histocompatibility complex class II molecule, HLA-DO, inhibits the class II antigen-processing pathway. HLA-DO, expressed in only a subset of antigen-presenting cells, binds HLA-DM and blocks HLA-DM-catalyzed peptide loading of class II molecules.
MeSH terms
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Antigen Presentation / immunology*
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B-Lymphocytes / immunology
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Catalysis
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HLA-D Antigens / immunology*
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Histocompatibility Antigens Class II*
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Humans
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T-Lymphocytes / immunology
Substances
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H-2O antigen
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H2-M antigens
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HLA-D Antigens
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HLA-DM antigens
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HLA-DO antigens
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Histocompatibility Antigens Class II