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    Nat Genet. 1998 Mar;18(3):243-50.

    Distribution of olfactory receptor genes in the human genome.

    Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D.

    CRBM, CNRS ERS 155, Montpellier, France.

    Erratum in:

    • Nat Genet 1998 May;19(1):102.

    We demonstrate that members of the olfactory receptor (OR) gene family are distributed on all but a few human chromosomes. Through FISH analysis, we show that OR sequences reside at more than 25 locations in the human genome. Their distribution is biased for terminal bands. Flow-sorted chromosomes were used to isolate 87 OR sequences derived from 16 chromosomes. Their sequence-relationships are indicative of the inter- and intrachromosomal duplications responsible for OR family expansion. The human genome has accumulated a striking number of dysfunctional copies: 72% of the sequences are pseudogenes. ORF-containing sequences predominate on chromosomes 7, 16 and 17.

    PMID: 9500546 [PubMed - indexed for MEDLINE]

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