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J Neurosci Methods. 1997 Dec 30;78(1-2):115-23.

A method for functional magnetic resonance imaging of olfaction.

Author information

  • 1Department of Neuroscience, Stanford University, CA 94305, USA. nsobel@leland/stanford.edu

Abstract

A method for generating olfactory stimuli for humans within a functional magnetic resonance imaging (fMRI) experimental design is described. The system incorporates a nasal-mask in which the change from odorant to no-odorant conditions occurs in less than 500 ms and is not accompanied by visual, auditory, tactile, or thermal cues. The mask provides an ordorant-free environment following prolonged ordorant presence. Specific imaging parameters that are conducive to the study of the human olfactory system are described. In a pilot study performed using these methods, the specific patterns of activation observed converged with published experimental and clinical findings.

PMID:
9497007
[PubMed - indexed for MEDLINE]
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