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FEBS Lett. 1998 Jan 30;422(2):165-9.

Effect of indomethacin on cell cycle dependent cyclic AMP fluxes in tobacco BY-2 cells.

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  • 1Dept. of Biology, Universiteit Antwerpen (UIA), Wilrijk, Belgium.


The evolution of adenosine 3',5'-cyclic monophosphate (cAMP) levels was investigated in synchronised tobacco BY-2 cells by virtue of a method based on immunoaffinity purification and analysis on electrospray tandem mass spectrometry. A transient peak in cAMP content was observed during the S and G1 phases of the cell cycle. Application of the prostaglandin inhibiting drug indomethacin at early S phase resulted in the loss of the cAMP peak in S phase and inhibited mitotic division. This inhibition of cAMP accumulation suggests the presence of a prostaglandin-dependent adenylyl cyclase activity, analogous to animal cyclases. A potential role for cAMP during the plant cell cycle is postulated.

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