Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 1998 Mar 6;279(5356):1528-30.

Muscle regeneration by bone marrow-derived myogenic progenitors.

Author information

  • 1H. San Raffaele-Telethon Institute for Gene Therapy (TIGET), 20132 Milan, Italy.

Erratum in

  • Science 1998 Aug 14;281(5379):923.

Abstract

Growth and repair of skeletal muscle are normally mediated by the satellite cells that surround muscle fibers. In regenerating muscle, however, the number of myogenic precursors exceeds that of resident satellite cells, implying migration or recruitment of undifferentiated progenitors from other sources. Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers. Genetically modified, marrow-derived myogenic progenitors could potentially be used to target therapeutic genes to muscle tissue, providing an alternative strategy for treatment of muscular dystrophies.

PMID:
9488650
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk