My NCBI | Sign In
RSS Settings
  • Search:

Display Settings:

Format

Send to:

Choose Destination

    Toxicol Lett. 1997 Dec;93(2-3):215-9.

    HIV protease inhibitors, saquinavir, indinavir and ritonavir: inhibition of CYP3A4-mediated metabolism of testosterone and benzoxazinorifamycin, KRM-1648, in human liver microsomes.

    Inaba T, Fischer NE, Riddick DS, Stewart DJ, Hidaka T.

    Department of Pharmacology, Faculty of Medicine, University of Toronto, Canada. t.inaba@utoronto.ca

    The protease inhibitors, ritonavir, indinavir and saquinavir, the most potent anti-HIV drugs developed to date, interact with many drugs by competing for CYP3A4, an enzyme central to the metabolism of a wide variety of compounds. Human liver microsomes were used to compare inhibition by these three protease inhibitors. The inhibition was the greatest with ritonavir and indinavir and less potent with saquinavir.

    PMID: 9486958 [PubMed - indexed for MEDLINE]

    Publication Types, MeSH Terms, Substances

    Publication Types:

    MeSH Terms:

    Substances:

    LinkOut - more resources

    Full Text Sources:

    Other Literature Sources:

    Molecular Biology Databases:

    Libraries:

    Supplemental Content

    Click here to read Click here to read Click here to read

    Related articles

    Cited by 2 PubMed Central articles

    Patient drug information

    • Saquinavir (Invirase®, Fortovase®)

      Saquinavir is used in combination with other medications to treat human immunodeficiency virus (HIV) infection in patients with or without acquired immunodeficiency syndrome (AIDS). Saquinavir is in a class of antiviral ...

    • Indinavir (Crixivan®)

      Indinavir is used to treat human immunodeficiency virus (HIV) infection in adults. It belongs to a class of drugs called protease inhibitors, which slow the spread of HIV infection in the body. It is usually taken with o...

    • Ritonavir (Norvir®, Norvir® Softgel)

      Ritonavir is used to treat human immunodeficiency virus (HIV) infection. It belongs to a class of drugs called protease (pro' tee ace) inhibitors, which slow the spread of HIV infection in the body. It is usually taken w...

    • Source: AHFS Consumer Medication Information

    All links from this record

    • Compound (MeSH Keyword)

      PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

    • Substance (MeSH Keyword)

      PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

    • Related Articles

      Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.

    • Cited in PMC

      Full-text articles in the PubMed Central Database that cite the current articles.

    Recent activity