Trends Biochem Sci. 1998 Jan;23(1):25-9.

A bacterial RNA that functions as both a tRNA and an mRNA.

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Department of Biology, Faculty of Science, Hirosaki University, Japan. muto@cc.hirosaki-u.ac.jp

Abstract

Bacterial tmRNA (transfer-messenger RNA, also known as 10Sa RNA) contains a tRNA-like structure in the 5'- and 3'-end sequences and an internal reading frame encoding a 'tag' peptide. The dual function of this molecule as both a tRNA and an mRNA facilitates a trans-translation reaction, in which a ribosome can switch between translation of a truncated mRNA and the tmRNA's tag sequence. The result is a chimeric protein with the tag peptide attached to the C-terminus of the truncated peptide.

PMID:: 9478132; [PubMed - indexed for MEDLINE]

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Review Structure and function of 10Sa RNA: trans-translation system. [Biochimie. 1996]
Review Structure and function of 10Sa RNA: trans-translation system.
Muto A, Sato M, Tadaki T, Fukushima M, Ushida C, Himeno H. Biochimie. 1996; 78(11-12):985-91.
Determinants on tmRNA for initiating efficient and precise trans-translation: some mutations upstream of the tag-encoding sequence of Escherichia coli tmRNA shift the initiation point of trans-translation in vitro. [RNA. 2001]
Determinants on tmRNA for initiating efficient and precise trans-translation: some mutations upstream of the tag-encoding sequence of Escherichia coli tmRNA shift the initiation point of trans-translation in vitro.
Lee S, Ishii M, Tadaki T, Muto A, Himeno H. RNA. 2001 Jul; 7(7):999-1012.
In vitro trans translation mediated by alanine-charged 10Sa RNA. [J Mol Biol. 1997]
In vitro trans translation mediated by alanine-charged 10Sa RNA.
Himeno H, Sato M, Tadaki T, Fukushima M, Ushida C, Muto A. J Mol Biol. 1997 May 23; 268(5):803-8.
Functional and structural analysis of a pseudoknot upstream of the tag-encoded sequence in E. coli tmRNA. [J Mol Biol. 1999]
Functional and structural analysis of a pseudoknot upstream of the tag-encoded sequence in E. coli tmRNA.
Nameki N, Felden B, Atkins JF, Gesteland RF, Himeno H, Muto A. J Mol Biol. 1999 Feb 26; 286(3):733-44.
Review Trans-translation: the tmRNA-mediated surveillance mechanism for ribosome rescue, directed protein degradation, and nonstop mRNA decay. [Biochemistry. 2007]
Review Trans-translation: the tmRNA-mediated surveillance mechanism for ribosome rescue, directed protein degradation, and nonstop mRNA decay.
Dulebohn D, Choy J, Sundermeier T, Okan N, Karzai AW. Biochemistry. 2007 Apr 24; 46(16):4681-93. Epub 2007 Mar 31.

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Cited by 35 PubMed Central articles

Label-free, multiplexed detection of bacterial tmRNA using silicon photonic microring resonators. [Biosens Bioelectron. 2012]
Label-free, multiplexed detection of bacterial tmRNA using silicon photonic microring resonators.
Scheler O, Kindt JT, Qavi AJ, Kaplinski L, Glynn B, Barry T, Kurg A, Bailey RC. Biosens Bioelectron. 2012 Jun-Jul; 36(1):56-61. Epub 2012 Apr 6.
Sequencing illustrates the transcriptional response of Legionella pneumophila during infection and identifies seventy novel small non-coding RNAs. [PLoS One. 2011]
Sequencing illustrates the transcriptional response of Legionella pneumophila during infection and identifies seventy novel small non-coding RNAs.
Weissenmayer BA, Prendergast JG, Lohan AJ, Loftus BJ. PLoS One. 2011 Mar 3; 6(3):e17570. Epub 2011 Mar 3.
Detection of NASBA amplified bacterial tmRNA molecules on SLICSel designed microarray probes. [BMC Biotechnol. 2011]
Detection of NASBA amplified bacterial tmRNA molecules on SLICSel designed microarray probes.
Scheler O, Kaplinski L, Glynn B, Palta P, Parkel S, Toome K, Maher M, Barry T, Remm M, Kurg A. BMC Biotechnol. 2011 Feb 28; 11:17. Epub 2011 Feb 28.

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