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Trends Biochem Sci. 1998 Jan;23(1):25-9.

A bacterial RNA that functions as both a tRNA and an mRNA.

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  • 1Department of Biology, Faculty of Science, Hirosaki University, Japan.


Bacterial tmRNA (transfer-messenger RNA, also known as 10Sa RNA) contains a tRNA-like structure in the 5'- and 3'-end sequences and an internal reading frame encoding a 'tag' peptide. The dual function of this molecule as both a tRNA and an mRNA facilitates a trans-translation reaction, in which a ribosome can switch between translation of a truncated mRNA and the tmRNA's tag sequence. The result is a chimeric protein with the tag peptide attached to the C-terminus of the truncated peptide.

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