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- Erratum in:
- J Infect Dis 1998 Jun;177(6):1778.
Doxycycline reduces mortality to lethal endotoxemia by reducing nitric oxide synthesis via an interleukin-10-independent mechanism.
Institute of General Pathology, University of Palermo, Italy.
It was demonstrated that doxycycline protected BALB/c mice injected intraperitoneally with bacterial lipopolysaccharide (LPS) against lethal septic shock. Doxycycline (at 1.5 mg/kg) exerted its protective effect by inhibiting nitrate production by an interleukin-10-independent mechanism. Experiments carried out in vitro also indicated that doxycycline inhibited NO synthesis by LPS-activated macrophages without inducing any significant modification in interleukin-10 release. These data suggest that the direct inhibition of nitrate release is the main mechanism of the antiinflammatory activity of doxycycline in septic shock.
PMID: 9466545 [PubMed - indexed for MEDLINE]
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Cited by 1 PubMed Central article
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Effects of chemically modified tetracyclines (CMTs) in sensitive, multidrug resistant and apoptosis resistant leukaemia cell lines.
Tolomeo M, Grimaudo S, Milano S, La Rosa M, Ferlazzo V, Di Bella G, Barbera C, Simoni D, D'Agostino P, Cillari E.
Br J Pharmacol. 2001 May; 133(2):306-14.
[Br J Pharmacol. 2001]