Abstract
Measurements of anti-phenolic glycolipid-I antibodies were made in 200 matched samples of capillary blood from the skin-smear site, venous blood collected on filter paper, and sera. A close correlation among the three samples was observed and a weaker correlation among the antibody levels and the average and skin-smear bacterial index. Capillary blood from the skin-smear site had a consistently higher level of antibodies in each sample than did the sera. The collection of capillary blood from skin-smear sites is a convenient and economical method of obtaining samples for serology and for measuring local antibody levels, and it may be more sensitive than measurements of antibodies in sera.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Antibodies, Bacterial / analysis*
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Antibodies, Bacterial / blood
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Antibodies, Bacterial / immunology
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Antigens, Bacterial*
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Child
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Disease Progression
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Drug Monitoring / methods
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Female
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Glycolipids / blood
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Glycolipids / immunology*
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Humans
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Immunoglobulin M / analysis*
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Immunoglobulin M / blood
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Immunoglobulin M / immunology
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Leprosy / diagnosis
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Leprosy / drug therapy
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Leprosy / immunology*
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Leprosy, Borderline / diagnosis
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Leprosy, Borderline / drug therapy
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Leprosy, Borderline / immunology
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Leprosy, Lepromatous / diagnosis
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Leprosy, Lepromatous / drug therapy
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Leprosy, Lepromatous / immunology
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Leprosy, Tuberculoid / diagnosis
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Leprosy, Tuberculoid / drug therapy
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Leprosy, Tuberculoid / immunology
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Male
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Middle Aged
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Sensitivity and Specificity
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Skin / blood supply*
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Skin / immunology*
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Skin / microbiology
Substances
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Antibodies, Bacterial
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Antigens, Bacterial
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Glycolipids
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Immunoglobulin M
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phenolic glycolipid I, Mycobacterium leprae