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1: Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1490-4.Click here to read Click here to read Links

Is the molten globule a third phase of proteins?

Pande VS, Rokhsar DS.

Department of Physics, University of California at Berkeley, Berkeley, CA 94720, USA.

The equilibrium properties of proteins are studied by Monte Carlo simulation of two simplified models of protein-like heteropolymers. These models emphasize the polymeric entropy of the fluctuating polypeptide chain. Our calculations suggest a generic phase diagram that contains a thermodynamically distinct "molten globule" state in addition to a rigid native state and a nontrivial unfolded state. The roles of side-chain packing and loop entropy are discussed.

PMID: 9465042 [PubMed - indexed for MEDLINE]

PMCID: PMC19058