J Mol Med (Berl). 1998 Jan;76(1):13-20.

Sequence and function of the two P domain potassium channels: implications of an emerging superfamily.

Goldstein SA, Wang KW, Ilan N, Pausch MH.

Source

Department of Pediatrics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA.

Abstract

A new superfamily of K+ channels has emerged in the past 2 years. Notable for possessing two pore-forming P domains in each subunit, members of the superfamily have been recognized through phylogeny from micro-organisms to humans. Four subfamilies of two P domain channels have been isolated thus far; among these are the first cloned examples of outward rectifier and open rectifier (or leak) K+ channels. The two P domain K+ channels offer a new perspective from which to glimpse the molecular basis for function and dysfunction of K+-selective ion channels.

PMID:: 9462864; [PubMed - indexed for MEDLINE]

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Potassium Channels

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Two-P potassium channels - IUPHAR Database of Receptors and Ion Channels

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