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1: Cytokine Growth Factor Rev. 1997 Sep;8(3):189-206.Click here to read Links

The interferon gamma (IFN-gamma) receptor: a paradigm for the multichain cytokine receptor.

Pestka S, Kotenko SV, Muthukumaran G, Izotova LS, Cook JR, Garotta G.

UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

With the purification and cloning of the interferon gamma (IFN-gamma) receptor chains the mechanism of IFN-gamma action and the resultant signal transduction events were delineated in remarkable detail. The interferon gamma (IFN-gamma) receptor complex consists of two chains: IFN-gammaR1, the ligand-binding chain, and IFN-gammaR2, the accessory chain. Binding of IFN-gamma causes oligomerization of the two IFN-gamma receptor subunits, IFN-gammaR1 and IFN-gammaR2, which initiates the signal transduction events: activation of Jak1 and Jak2 receptor associated protein tyrosine kinases, phosphorylation of the IFN-gammaR1 intracellular domain on Tyr440 followed by phosphorylation and activation of Stat1alpha, the latent transcriptional factor. With all these steps established, the IFN-gamma receptor complex has provided the basic model for understanding the receptors for other members of the family of class II cytokine receptors.

PMID: 9462485 [PubMed - indexed for MEDLINE]

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