The structure of GABPalpha/beta: an ETS domain- an...[Science. 1998]

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1: Science. 1998 Feb 13;279(5353):1037-41. Links

Comment in:: Science. 1998 Feb 13;279(5353):1000-2.

The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA.

Batchelor AH, Piper DE, de la Brousse FC, McKnight SL, Wolberger C.

Department of Biophysics and Biophysical Chemistry and the Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

GA-binding protein (GABP) is a transcriptional regulator composed of two structurally dissimilar subunits. The alpha subunit contains a DNA-binding domain that is a member of the ETS family, whereas the beta subunit contains a series of ankyrin repeats. The crystal structure of a ternary complex containing a GABPalpha/beta ETS domain-ankyrin repeat heterodimer bound to DNA was determined at 2. 15 angstrom resolution. The structure shows how an ETS domain protein can recruit a partner protein using both the ETS domain and a carboxyl-terminal extension and provides a view of an extensive protein-protein interface formed by a set of ankyrin repeats. The structure also reveals how the GABPalpha ETS domain binds to its core GGA DNA-recognition motif.

PMID: 9461436 [PubMed - indexed for MEDLINE]

Identification of redox-sensitive cysteines in GA-binding protein-alpha that regulate DNA binding and heterodimerization.
J Biol Chem. 1998 Mar 13; 273(11):6203-9.

[J Biol Chem. 1998]
Requirements for selective recruitment of Ets proteins and activation of mb-1/Ig-alpha gene transcription by Pax-5 (BSAP).
Nucleic Acids Res. 2003 Oct 1; 31(19):5483-9.

[Nucleic Acids Res. 2003]
Identification of amino acid residues in the ETS transcription factor Erg that mediate Erg-Jun/Fos-DNA ternary complex formation.
J Biol Chem. 2001 May 18; 276(20):17181-9. Epub 2001 Feb 23.

[J Biol Chem. 2001]
ReviewWhen Ets transcription factors meet their partners.
Bioessays. 2002 Apr; 24(4):362-70.

[Bioessays. 2002]
ReviewRegulation of Ets function by protein - protein interactions.
Oncogene. 2000 Dec 18; 19(55):6514-23.

[Oncogene. 2000]
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Guillon N, Tirode F, Boeva V, Zynovyev A, Barillot E, Delattre O. PLoS One. 2009; 4(3):e4932. Epub 2009 Mar 23.

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Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli.
Sandqvist A, Björk JK, Akerfelt M, Chitikova Z, Grichine A, Vourc'h C, Jolly C, Salminen TA, Nymalm Y, Sistonen L. Mol Biol Cell. 2009 Mar; 20(5):1340-7. Epub 2009 Jan 7.

[Mol Biol Cell. 2009]
Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha.
Kang HS, Nelson ML, Mackereth CD, Schärpf M, Graves BJ, McIntosh LP. J Mol Biol. 2008 Mar 28; 377(3):636-46. Epub 2008 Jan 30.

[J Mol Biol. 2008]
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Structures reported by this article

Mouse Gabp AlphaBETA DOMAIN BOUND TO DNA

PDB: 1AWC

Source: Mus musculus, synthetic construct

Method: X-Ray Diffraction | Resolution: 2.15 Å

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