Neuron. 1998 Jan;20(1):95-102.

RGS9, a GTPase accelerator for phototransduction.

Source

Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA.

Abstract

The rod outer segment phototransduction GAP (GTPase-accelerating protein) has been identified as RGS9, a member of the RGS family of G alpha GAPs. RGS9 mRNA expression is specific for photoreceptor cells, and RGS9 protein colocalizes with other phototransduction components to photoreceptor outer segment membranes. The RGS domain of RGS9 accelerates GTP hydrolysis by the visual G protein transducin (G alpha(t)), and this acceleration is enhanced by the gamma subunit of the phototransduction effector cGMP phosphodiesterase (PDEgamma). These unique properties of RGS9 match those of the rod outer segment GAP and implicate it as a key element in the recovery phase of visual transduction.

PMID:: 9459445; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Modulation of transducin GTPase activity by chimeric RGS16 and RGS9 regulators of G protein signaling and the effector molecule. [Biochemistry. 1999]
Modulation of transducin GTPase activity by chimeric RGS16 and RGS9 regulators of G protein signaling and the effector molecule.
McEntaffer RL, Natochin M, Artemyev NO. Biochemistry. 1999 Apr 20; 38(16):4931-7.
The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit. [Proc Natl Acad Sci U S A. 1999]
The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit.
Makino ER, Handy JW, Li T, Arshavsky VY. Proc Natl Acad Sci U S A. 1999 Mar 2; 96(5):1947-52.
The effector enzyme regulates the duration of G protein signaling in vertebrate photoreceptors by increasing the affinity between transducin and RGS protein. [J Biol Chem. 2000]
The effector enzyme regulates the duration of G protein signaling in vertebrate photoreceptors by increasing the affinity between transducin and RGS protein.
Skiba NP, Hopp JA, Arshavsky VY. J Biol Chem. 2000 Oct 20; 275(42):32716-20.
Review RGS proteins: lessons from the RGS9 subfamily. [Prog Nucleic Acid Res Mol Biol...]
Review RGS proteins: lessons from the RGS9 subfamily.
Cowan CW, He W, Wensel TG. Prog Nucleic Acid Res Mol Biol. 2001; 65:341-59.
Review G proteins and phototransduction. [Annu Rev Physiol. 2002]
Review G proteins and phototransduction.
Arshavsky VY, Lamb TD, Pugh EN Jr. Annu Rev Physiol. 2002; 64:153-87.

See reviews... See all...

Cited by 59 PubMed Central articles

Light-induced translocation of RGS9-1 and Gβ5L in mouse rod photoreceptors. [PLoS One. 2013]
Light-induced translocation of RGS9-1 and Gβ5L in mouse rod photoreceptors.
Tian M, Zallocchi M, Wang W, Chen CK, Palczewski K, Delimont D, Cosgrove D, Peng YW. PLoS One. 2013; 8(3):e58832. Epub 2013 Mar 28.
The relationship between slow photoresponse recovery rate and temporal resolution of vision. [J Neurosci. 2012]
The relationship between slow photoresponse recovery rate and temporal resolution of vision.
Umino Y, Herrmann R, Chen CK, Barlow RB, Arshavsky VY, Solessio E. J Neurosci. 2012 Oct 10; 32(41):14364-73.
A constitutively active Gα subunit provides insights into the mechanism of G protein activation. [Biochemistry. 2012]
A constitutively active Gα subunit provides insights into the mechanism of G protein activation.
Singh G, Ramachandran S, Cerione RA. Biochemistry. 2012 Apr 17; 51(15):3232-40. Epub 2012 Apr 5.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

RGS9, a GTPase accelerator for phototransduction.
RGS9, a GTPase accelerator for phototransduction.
Neuron. 1998 Jan ;20(1):95-102.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

RGS9, a GTPase accelerator for phototransduction.

Source

Abstract

Publication Types, MeSH Terms, Substances, Secondary Source ID, Grant Support

Publication Types

MeSH Terms

Substances

Secondary Source ID

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Miscellaneous

Supplemental Content

Save items

Related citations in PubMed

Cited by 59 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information