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    Nature. 1998 Jan 22;391(6665):357-62.

    Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction.

    Glinka A, Wu W, Delius H, Monaghan AP, Blumenstock C, Niehrs C.

    Source

    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany.

    Abstract

    The Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity, the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which encodes Dkk-1, a secreted inducer of Spemann's organizer in Xenopus and a member of a new protein family. Injections of mRNA and antibody indicate that dkk-1 is sufficient and necessary to cause head induction. dkk-1 s a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors.

    PMID:
    9450748
    [PubMed - indexed for MEDLINE]

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