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Arzneimittelforschung. 1997 Nov;47(11A):1306-9.

Pivagabine: a novel psychoactive drug.

Author information

  • 1Aziende Chimiche Riunite Angelini Francesco S.p.A. (ACRAF S.p.A.), Medical Department, Rome, Italy.

Abstract

Pivagabine (4-[(2,2-dimethyl-1-oxopropyl)amino]butanoic acid, CAS 69542-93-4, Tonerg) is a metabolically stable compound with a modulatory effect on some biochemical parameters involved in stress conditions (corticotropin releasing factor, neurosteroids). The compound, tested in several animal models, prevents stress-correlated behavioural deficits. Moreover, pivagabine has a highly significant therapeutic potential in clinical conditions characterized by manifestations of psychological distress due to an inadequate management of stressful events.

PMID:
9450153
[PubMed - indexed for MEDLINE]
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