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Drug Alcohol Depend. 1997 Dec 15;48(3):153-8.

Development of a therapeutic vaccine for the treatment of cocaine addiction.

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  • ImmuLogic Pharmaceutical Corporation, Waltham, MA 02154, USA. FoxB@ImmuLogic.com


No pharmacotherapies have yet been approved for the treatment of cocaine addiction. One new approach is to block the effects of cocaine with anti-cocaine antibodies induced by a therapeutic cocaine vaccine. A cocaine vaccine has been developed which induces a cocaine-specific antibody response in rodents. The antibody binds to cocaine in the circulation and can be shown to inhibit the ability of cocaine to enter the brain. Furthermore, anti-cocaine antibody can inhibit cocaine self-administration in rats. These data suggest that a cocaine vaccine may be a powerful therapeutic tool. The intent is to immunized motivated patients with the vaccine as part of a comprehensive treatment program. If the patient uses cocaine after being vaccinated, the antibody will inhibit the reinforcing activity of cocaine and decrease the likelihood of relapse.

[PubMed - indexed for MEDLINE]
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