Format

Send to

Choose Destination
See comment in PubMed Commons below
Br J Surg. 1997 Dec;84(12):1670-4.

Gastric intramucosal pH predicts death in severe acute pancreatitis.

Author information

  • 1Department of Surgery, Faculty of Medicine and Health Sciences, University of Auckland, New Zealand.

Abstract

BACKGROUND:

This study tested the hypothesis that gastric intramucosal pH (pHi) can predict death in severe acute pancreatitis.

METHODS:

Seventeen consecutive patients with predicted severe acute pancreatitis were studied prospectively. Four died from complications related to pancreatitis. Gastric pHi was measured by nasogastric tonometry at least every 12 h for the first 48 h after admission and then on a daily basis during the first week.

RESULTS:

The lowest pHi recorded during the first 48 h was significantly less in those admitted to the intensive care unit than that in those who remained on the surgical ward (P = 0.0015) and in nonsurvivors compared with the survivors (P = 0.009). A receiver-operator characteristic curve defined a pHi of 7.25 as the optimal cut-off point to predict death (sensitivity 100 per cent, specificity 77 per cent, overall predictive value 82 per cent).

CONCLUSION:

These results suggest that splanchnic ischaemia may be an important determinant of outcome in patients with severe acute pancreatitis.

PMID:
9448612
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk