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Biochem Biophys Res Commun. 1998 Jan 14;242(2):407-12.

cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3C.

Author information

  • 1Molecular Medicine Unit, St. James's University Hospital, University of Leeds, United Kingdom. mmeeart@stjames.leeds.ac.uk

Abstract

We report the cloning and characterization of a novel human kinesin-like gene with strong homology to the mouse kinesin Kif3c. The full-length cDNA contains an open reading frame of 2382 nucleotides encoding a predicted 793 amino acid peptide that includes a 389 amino acid motor domain conserved among other kinesins. PCR and DNA sequence analysis of PAC clones containing the human KIF3C sequence revealed that the gene contains 8 exons. All introns have the conserved GT and AG dinucleotides present at their donor and acceptor sites, respectively. We have localized KIF3C to chromosome band 2p23 by fluorescence in situ hybridization.

PMID:
9446808
[PubMed - indexed for MEDLINE]
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