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Psychiatr Clin North Am. 1997 Dec;20(4):723-39.

Serotonergic systems.

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  • 1Laboratório de Psicofarmacologia, Universidade de São Paulo, Brazil.


Since its identification in neurons of the central nervous systems (CNS), serotonin (5-HT) has been implicated in the pathophysiology of psychiatric disorders, such as schizophrenia, depression, generalized anxiety disorder (GAD), panic disorder (PD), and obsessive-compulsive disorder (OCD). These findings have stimulated research on brain 5-HT pathways, especially during the last two decades as more selective drugs have been introduced into medical practice. This article reviews selected topics relevant for psychiatry.

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