Science. 1976 Mar 26;191(4233):1262-4.

Hemoglobin synthesis in somatic cell hybrids: independent segregation of the human alpha- and beta-globin genes.

Abstract

Hybrid somatic cells containing a partial complement of human chromosomes were used to demonstrate that the human alpha- and beta-globin genes are located on different chromosomes. Two cell lines consisting of a cross of mouse with human fibroblasts contained the human alpha- and not the beta-globin gene, while a cross of human marrow cells with mouse erythroleukemia cells expressed the human beta- but not the alpha-globin gene.

PMID:: 943846; [PubMed - indexed for MEDLINE]

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Hemoglobins

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Hemoglobin synthesis in somatic cell hybrids: coexpression of mouse with human or chinese hamster globin genes in interspecific somatic cell hybrids of mouse erythroleukemia cells. [Proc Natl Acad Sci U S A. 1975]
Hemoglobin synthesis in somatic cell hybrids: coexpression of mouse with human or chinese hamster globin genes in interspecific somatic cell hybrids of mouse erythroleukemia cells.
Deisseroth A, Barker J, Anderson WF, Nienhuis. Proc Natl Acad Sci U S A. 1975 Jul; 72(7):2682-6.
Hemoglobin synthesis in somatic cell hybrids: globin gene expression in hybrids between mouse erythroleukemia and human marrow cells or fibroblasts. [Proc Natl Acad Sci U S A. 1975]
Hemoglobin synthesis in somatic cell hybrids: globin gene expression in hybrids between mouse erythroleukemia and human marrow cells or fibroblasts.
Deisseroth A, Burk R, Picciano D, Anderson WF, Nienhuis A, Minna J. Proc Natl Acad Sci U S A. 1975 Mar; 72(3):1102-6.
Activation of human beta-globin genes from nonerythroid cells by fusion with murine erythroleukemia cells. [Proc Natl Acad Sci U S A. 1980]
Activation of human beta-globin genes from nonerythroid cells by fusion with murine erythroleukemia cells.
Pyati J, Kucherlapati RS, Skoultchi AI. Proc Natl Acad Sci U S A. 1980 Jun; 77(6):3435-9.
Review Somatic cell hybrid mapping panels. [Exp Cell Res. 1984]
Review Somatic cell hybrid mapping panels.
Kamarck ME, Barker PE, Miller RL, Ruddle FH. Exp Cell Res. 1984 May; 152(1):1-14.
Review The control of gene expression in somatic cell hybrids. [Int Rev Cytol. 1976]
Review The control of gene expression in somatic cell hybrids.
Bernhard HP. Int Rev Cytol. 1976; 47:289-325.

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Cited by 5 PubMed Central articles

Genomic evidence for independent origins of beta-like globin genes in monotremes and therian mammals. [Proc Natl Acad Sci U S A. 2008]
Genomic evidence for independent origins of beta-like globin genes in monotremes and therian mammals.
Opazo JC, Hoffmann FG, Storz JF. Proc Natl Acad Sci U S A. 2008 Feb 5; 105(5):1590-5. Epub 2008 Jan 23.
Adult and fetal human globin genes are expressed following chromosomal transfer into MEL cells. [Proc Natl Acad Sci U S A. 1985]
Adult and fetal human globin genes are expressed following chromosomal transfer into MEL cells.
Papayannopoulou TH, Lindsley D, Kurachi S, Lewison K, Hemenway T, Melis M, Anagnou NP, Najfeld V. Proc Natl Acad Sci U S A. 1985 Feb; 82(3):780-4.
Assignment of human beta-, gamma-, and delta-globin genes to the short arm of chromosome 11 by chromosome sorting and DNA restriction enzyme analysis. [Proc Natl Acad Sci U S A. 1979]
Assignment of human beta-, gamma-, and delta-globin genes to the short arm of chromosome 11 by chromosome sorting and DNA restriction enzyme analysis.
Lebo RV, Carrano AV, Burkhart-Schultz K, Dozy AM, Yu LC, Kan YW. Proc Natl Acad Sci U S A. 1979 Nov; 76(11):5804-8.

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