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Scand J Gastroenterol. 1997 Dec;32(12):1201-3.

Helicobacter pylori infection in patients with chronic pancreatitis and duodenal ulcer.

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  • 1Dept. of Medicine, Herning Central Hospital, Denmark.

Abstract

BACKGROUND:

The prevalence of duodenal ulcer is high in patients with chronic pancreatitis. Patients with simple duodenal ulcer without chronic pancreatitis are mostly Helicobacter pylori-infected, and the prevalence of IgG seropositivity is > 95%. The prevalence of H. pylori infection in patients with chronic pancreatitis is not known.

METHODS:

IgG antibodies against H. pylori were measured in a cross-sectional survey of consecutive patients who had their exocrine pancreas function examined with a Lundh meal test in the period 1988-95 and in a control group of patients with simple duodenal ulcer.

RESULTS:

Twenty-seven per cent of the patients with chronic pancreatitis had duodenal ulcer during the observation period. The prevalence of IgG antibodies against H. pylori was 22% in patients with chronic pancreatitis without duodenal ulcer as compared with 27% with non-organic abdominal pain. The prevalence of IgG antibodies against H. pylori was 60% in patients with chronic pancreatitis complicated by duodenal ulcer as compared with 86% in controls with simple duodenal ulcer.

CONCLUSIONS:

H. pylori infection contributes but may not be the only cause of duodenal ulcer in patients with chronic pancreatitis.

PMID:
9438316
[PubMed - indexed for MEDLINE]
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