Structure of the sucrose-specific porin ScrY from ...[Nat Struct Biol. 1998]

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1: Nat Struct Biol. 1998 Jan;5(1):37-46.Links

Comment in:: Nat Struct Biol. 1998 Jan;5(1):6-8.

Structure of the sucrose-specific porin ScrY from Salmonella typhimurium and its complex with sucrose.

Forst D, Welte W, Wacker T, Diederichs K.

Institut für Biophysik und Strahlenbiologie, Albert-Ludwigs-Universität, Freiburg im Breisgau, Germany.

The X-ray structure of a sucrose-specific porin (ScrY) from Salmonella typhimurium has been determined by multiple isomorphous replacement at 2.4 A resolution both in its uncomplexed form and with bound sucrose. ScrY is a noncrystallographic trimer of identical subunits, each with 413 structurally well-defined amino acids. A monomer is built up of 18 anti-parallel beta-strands surrounding a hydrophilic pore, with a topology closely similar to that of maltoporin. Two non-overlapping sucrose-binding sites were identified in difference Fourier maps. The higher permeability for sucrose of ScrY as compared to maltoporin is mainly accounted for by differences in their pore-lining residues.

PMID: 9437428 [PubMed - indexed for MEDLINE]

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Structures reported by this article

Sucrose-Specific Porin

PDB: 1A0S

Source: Salmonella enterica subsp. enterica serovar Typhimurium

Method: X-Ray Diffraction | Resolution: 2.4 Å
» See all 2 structures...

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